The White House has issued a direct response to Rosie O’Donnell following her recent guest-hosting stint on Jimmy Kimmel Live. During her appearance on the late-night program, the 64-year-old entertainer repeatedly criticized President Donald Trump, culminating in a musical performance where she urged him to resign from office. O’Donnell, who has a history of public tension with the president dating back nearly two decades, frequently referenced Trump throughout her monologues during the week.

In a statement provided to the media, a White House representative fired back at the host, describing O’Donnell as a nasty woman and a total slob. The spokesperson further suggested that her judgment is impaired, claiming that her brain has been completely destroyed by what they termed Trump Derangement Syndrome. O’Donnell, for her part, appeared to embrace the criticism during her final broadcast, introducing herself as nasty Rosie O’Donnell before proceeding with her set.

This exchange marks the latest chapter in a long-standing feud between the two figures. O’Donnell, who spent time living in Ireland before returning to the United States this year for her stage show and television appearances, has denied speculation regarding a permanent return to a late-night hosting chair. She has noted, however, that she is open to future projects on streaming platforms once political dynamics shift.

While the White House remains critical of her remarks, O’Donnell has found support among other industry figures, including Barbra Streisand. The comedian continues to navigate her return to the public eye while maintaining her stance on the current administration.